The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease.
نویسندگان
چکیده
The treatment of Chagas disease is limited by the frequent cutaneous side effects of benznidazole. We tested the use of steroids plus escalating doses of benznidazole to prevent this complication in 17 adult patients with chronic Trypanosoma cruzi infection and found extremely good tolerance. A randomized trial is warranted.
منابع مشابه
Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis.
BACKGROUND AND OBJECTIVES The recent significant increase in the number of immigrants entering the European Union from South and Central America means that chronic Chagas' disease is an increasingly frequent diagnosis among immigrants in Europe. Our objectives were to evaluate published evidence on the treatment of chronic Chagas' disease with benznidazole and on the potential benefits of this ...
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متن کاملChronic phase of Chagas disease: why should it be treated? A comprehensive review.
The pathogenesis and evolutive pattern of Chagas disease suggests that the chronic phase should be more widely treated in order to (i) eliminate Trypanosoma cruzi and prevent new inflammatory foci and the extension of tissue lesions, (ii) promote tissue regeneration to prevent fibrosis, (iii) reverse existing fibrosis, (iv) prevent cardiomyopathy, megaoesophagus and megacolon and (v) reduce or ...
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ورودعنوان ژورنال:
- Pathogens and global health
دوره 107 3 شماره
صفحات -
تاریخ انتشار 2013